- Original Article
- Other
- Korean parents’ perceptions of the challenges and needs on school re-entry during or after childhood and adolescent cancer: a multi-institutional survey by Korean Society of Pediatric Hematology and Oncology
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Jun Ah Lee, Jae Min Lee, Hyeon Jin Park, Meerim Park, Byung Kiu Park, Hee Young Ju, Ji Yoon Kim, Sang Kyu Park, Young Ho Lee, Ye Jee Shim, Heung Sik Kim, Kyung Duk Park, Yeon-Jung Lim, Hee Won Chueh, Ji Kyoung Park, Soon Ki Kim, Hyoung Soo Choi, Hyo Seop Ahn, Jeong Ok Hah, Hyoung Jin Kang, Hee Young Shin, Mee Jeong Lee
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Clin Exp Pediatr. 2020;63(4):141-145. Published online November 14, 2019
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Question: What are the parental needs and challenges when their children return to school after cancer?
Finding: In addition to scholastic aptitude-oriented programs, emotional and psychosocial support is necessary for a successful return to school.
Meaning: Pediatric oncologists should actively engage in improving oncology practices to better integrate individualized school plans and educate peers and teachers to improve health literacy to make them understand the needs of children with cancer. |
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- Oncology
- Metformin displays in vitro and in vivo antitumor effect against osteosarcoma
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Yunmi Ko, Aery Choi, Minyoung Lee, Jun Ah Lee
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Clin Exp Pediatr. 2016;59(9):374-380. Published online September 21, 2016
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Purpose Patients with unresectable, relapsed, or refractory osteosarcoma need a novel therapeutic agent. Metformin is a biguanide derivative used in the treatment of type II diabetes, and is recently gaining attention in cancer research. MethodsWe evaluated the effect of metformin against human osteosarcoma. Four osteosarcoma cell lines (KHOS/NP, HOS, MG-63, U-2 OS) were treated with metformin and cell proliferation was evaluated using... |
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- Case Report
- Infection
- Tuberculosis-associated hemophagocytic lymphohistiocytosis in adolescent diagnosed by polymerase chain reaction
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Ju-Hee Seo, Jun Ah Lee, Dong Ho Kim, Joongbum Cho, Jung Sub Lim
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Clin Exp Pediatr. 2016;59(1):43-46. Published online January 22, 2016
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We present a case of tuberculosis-associated hemophagocytic lymphohistiocytosis in a 14-year-old girl. The patient presented with weight loss, malaise, fatigue, prolonged fever, and generalized lymphadenopathy. Laboratory investigation revealed pancytopenia (white blood cells, 2,020 cells/µL; hemoglobin, 10.2 g/dL; platelets, 52,000 cells/µL), hypertriglyceridemia (229 mg/dL), and hyperferritinemia (1,420 ng/mL). Bone marrow biopsy showed a hypocellular bone marrow with a large numbers of... |
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- Review Article
- Osteosarcoma in Korean children and adolescents
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Jun Ah Lee
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Clin Exp Pediatr. 2015;58(4):123-128. Published online April 22, 2015
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Osteosarcoma is the most frequent primary bone tumor. Advances in combination chemotherapy and surgical technique have greatly improved the survival of patients with osteosarcoma. In Korea, improvements in osteosarcoma treatment have been made over the past two decades. The 5-year event-free survival rate of Korean children and adolescents with localized disease is 64.6%, comparable to that of American or European... |
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- Original Article
- High-dose chemotherapy and autologous peripheral blood stem cell transplantation in the treatment of children and adolescents with Ewing sarcoma family of tumors
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Juhee Seo, Dong Ho Kim, Jung Sub Lim, Jae-Soo Koh, Ji Young Yoo, Chang-Bae Kong, Won Seok Song, Wan Hyeong Cho, Dae-Geun Jeon, Soo-Yong Lee, Jun Ah Lee
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Clin Exp Pediatr. 2013;56(9):401-406. Published online September 30, 2013
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Purpose We performed a pilot study to determine the benefit of high-dose chemotherapy and autologous peripheral blood stem cell transplantation (HDCT/autoPBSCT) for patients with Ewing sarcoma family of tumors. MethodsWe retrospectively analyzed the data of patients who received HDCT/autoPBSCT at Korea Cancer Center Hospital. Patients with relapsed, metastatic, or centrally located tumors were eligible for the study. ResultsA total of 9 patients (3... |
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- Evaluation of immunogenicity of the 2008-2009 seasonal influenza vaccines by microneutralization test
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Seung Youn Kim, Yun Kyung Kim, Byung Wook Eun, Nam Hee Kim, Eun Kyeong Kang, Byong Sop Lee, Jung Sub Lim, Jun Ah Lee, Dong Ho Kim
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Clin Exp Pediatr. 2012;55(12):474-480. Published online December 20, 2012
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Purpose For evaluating the immunogenicity of an influenza vaccine, the microneutralization (MN) test has a higher sensitivity and specificity as compared to the hemagglutination inhibition (HI) test. However, the MN test is more time consuming and is difficult to standardize. We performed the MN test to determine its usefulness as an alternative or complementary test to the HI test for evaluating... |
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- Case Report
- Candida tropicalis arthritis of the elbow in a patient with Ewing's sarcoma that successfully responded to itraconazole
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Seung Youn Kim, Jung Sub Lim, Dong Hwan Kim, Hyeon Jeong Lee, Joong Bum Cho, Jun Ah Lee, Dong Ho Kim
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Clin Exp Pediatr. 2011;54(9):385-388. Published online September 30, 2011
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Fungal infections are rarely responsible for arthritis. Few cases of fungal arthritis have been reported, even in immunocompromised hosts susceptible to low-virulence organisms. Herein, the authors report the first case of Candida tropicalis arthritis in a child with a solid tumor. A 13-year-old boy with Ewing's sarcoma developed arthritis in his elbow during the neutropenic period after chemotherapy. Despite treatment... |
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- Original Article
- Pulmonary tuberculosis misdiagnosed as lung Metastasis in childhood cancer patients
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Hyun Rae KK, Dong Whand Lim, Kang Min, Kyung Duk Park, Jun Ah Lee, Soo Yeon Cho, Yoon Hoh Kook, Hee Youn Kim, Dong Ho Kim
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Clin Exp Pediatr. 2009;52(8):904-909. Published online August 15, 2009
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Purpose:The differential diagnosis for a pulmonary nodule is intriguing in cancer patients. Metastasis might be a preferential
diagnosis, and yet possibilities of other medical conditions still exist. Pulmonary tuberculosis should be enlisted in the differential
diagnosis for a pulmonary nodule in cancer patients in Korea. This study was aimed at analyzing the incidence and clinical features
of pulmonary tuberculosis that were misdiagnosed as... |
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- Bilateral retinoblastoma: Long-term follow-up results
from a single institution
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Sang Yul Choi, Dong Hwan Kim, Kang Min Lee, Hyun Jae Lee, Mi-Sook Kim, Tai-Won Lee, Sang Wook Choi, Dong Ho Kim, Kyung Duk Park, Jun Ah Lee
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Clin Exp Pediatr. 2009;52(6):674-679. Published online June 15, 2009
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Purpose : The authors aimed to analyze the long-term effects of treatments, especially external beam radiotherapy (EBRT), in bilateral retinoblastoma patients.
Methods : This retrospective study analyzed the medical records of 22 bilateral retinoblastoma patients who were registered between October, 1987 and October, 1998 and followed-up for more than 10 years. They were treated by enucleation, EBRT, and systemic chemotherapy.... |
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- Serum methotrexate level is inversely related to the outcome of osteosarcoma patients
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Jun Ah Lee, Min Suk Kim, Jin Kyung Lee, Dong Ho Kim, Young Joon Hong, Won Seok Song, Wan Hyeong Cho, Soo-Yong Lee, Jung Sub Lim, Kyung Duk Park, Dae-Geun Jeon
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Clin Exp Pediatr. 2009;52(5):581-587. Published online May 15, 2009
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Purpose : To evaluate the correlation between serum methotrexate (MTX) peak levels and clinical outcome of osteosarcoma, as well as to determine the correlation of these levels with the histologic response and event-free survival (EFS).
Methods : To maintain the homogeneity of the study population, we selected 52 patients with localized extremity osteosarcoma who had received two cycles of neoadjuvant... |
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- Review Article
- Malignancies in children who present with bone pain
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Jun Ah Lee
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Clin Exp Pediatr. 2008;51(8):792-796. Published online August 15, 2008
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Bone pain in a child could be associated with cancer as an initial manifestation of the disease. The childhood malignancies that frequently present bone pain are leukemia, neuroblastoma, and primary bone tumors such as osteosarcoma and Ewing sarcoma. Persistent bone or joint pain associated with swelling, mass, or limitation of motion implies underlying serious causes. Systemic manifestations such as lymphadenopathy,... |
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- Original Article
- The optimal conditions to improve retrovirus-mediated
transduction efficiency to NIH 3T3 cells
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Jun Ah Lee, Kang-Min Lee, Hyun Jae Lee, Yun Jeong Lee, Dong Ho Kim, Jung Sub Lim, Kyung-Duk Park
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Clin Exp Pediatr. 2007;50(10):1011-1017. Published online October 15, 2007
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Purpose : We tried to assess the optimal conditions to improve low transduction efficiency and their effect on target cells.
Methods : Cultured NIH 3T3 cells were incubated with retroviral vectors bearing an enhanced green fluorescent protein (eGFP) gene. We varied the ratio of viral vectors to target cells (1:1-1:8) and the number of transfections (X1, X2), and compared transduction... |
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- Immunomodulation Therapy in Aplastic Anemia : Relapse Rate, Complications
and Long-term Survival During Follow-up for More than 1 Year
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Jun Ah Lee, Hyoung Jin Kang, Hyo Jeong Han, Hyoung Soo Choi, Eun Sun Yoo, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
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Clin Exp Pediatr. 1998;41(6):775-784. Published online June 15, 1998
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Purpose : We evaluated the response to immunomodulation therapy, long-term survival and relapse
rate of aplastic anemia during follow-up for more than 1 year.
Methods : Twenty-eight children, with moderate to severe aplastic anemia were followed for more
than one year and 7 children expired after therapy, were analyzed. Antilymphocyte globulin(ALG) or
antithymocyte globulin(ATG) by itself was given to 27 patients, and cyclosporine A(CsA)... |
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- Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
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Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
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Clin Exp Pediatr. 1998;41(2):209-215. Published online February 15, 1998
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Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG).
Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment.
Results... |
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- A Result of Treatment of Malignant Germ Cell Tumors in Childhood
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Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
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Clin Exp Pediatr. 1997;40(12):1707-1718. Published online December 15, 1997
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Purpose : Germ cell tumors have variable clinical characteristics according to the age,
sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the
clinical characteristics, response to the treatment, and prognostic factors were analyzed.
Methods : Medical records of 57 children who were diagnosed as malignant germ cell
tumor in Seoul National University Children' s Hospital from January 1986 till June 1996
were... |
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